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Watch for symptoms like muscle weakness, numbness, irregular heartbeat, or unusual bruisingthese require immediate medical attention

Effect of JNJ-42165279 on anandamide levels Plasma concentrations of JNJ-42165279 correlated strongly with AEA levels at the corresponding time point (r s [133] = 0.67, p 5% of participants in any treatment arm are reported in Supplementary Table S7 (for all AEs see Supplementary Tables S8)

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For example, after stopping GLP-1 agonists, appetite resumes

doi: 10.1056/NEJMoa2204705 177 MindellJ